A novel work from the Kuchroo’s lab contributes considerably to our understanding of the various subsets of IL-17-producing cells, with delimitation of non-pathogenic from pathogenic Th17 cells. This is very important because even though there is increasing evidence that IL-17-producing Th17 cells are not always detrimental to host, there is still a long way to […]
Since, I have a long-lasting interest in the Ikaros family members, and a more recent one on IL-17 production, I do not resist making an entry on this article: Aiolos promotes Th17 differentiation by directly silencing Il2 expression. It is clearly established that IL-2 inhibits Th17 differentiation, by interfering with IL-6-dependent signaling events, such as […]
Back from the 3rd ECI conference 2012! Everyday, for 3 days, there were 4 plenary sessions in the morning and 12 workshops in the afternoon to choose from, thus it was important to go through the program well in advance :] This year the line up was very very good and some talks were simply […]
Here is a very elegant story about IL-17-producing γδ T cells (γδ17 cells), from Haas and colleagues in Prinz’s lab. They undertook very astute and clever approaches and created various original chimeras to demonstrate that there is only a narrowed window of opportunity, which occurs in the fetal thymus, for the development of γδ17 cells. […]
A quick note to say that I will go to the ECI conference in Glasgow to present a poster with some data on «Transcriptional and epigenetic signatures of pro-inflammatory γδ T cell subsets». Thus, if you want to have a look here is the link: 3rd European Congress of Immunology, Glasgow, Scotland | 5 – […]
Once again, I do not resist spreading some advertising. But this time it is not for me! It is for friends who are working in my previous institute – the MRC centre for Immune Regulation University of Birmingham in United Kingdom. On top of that it is really funny since this is the first paper […]
Back from the conference, filled up with news about the novel hot topics in the field and with challenging discussions with some of the currently leading researchers on the ever growing surprising γδ T cells! But before, just to let you know, Freiburg (im Breisgau), nicely situated in the south of Germany some 50 km […]
A quick note to let everyone know that I will go to the gamma-delta T cell conference to present a poster with some data on « Transcriptional and epigenetic signatures of pro-inflammatory γδ T cell subsets » Thus, if you want to read more here is the link: 5th γδ T cell conference in Freiburg. There is […]
Back to some of my old “favorite” cells, the IL-4-producing CD4 T cells :] It is well established that IL-4-producing CD4 T cells can be categorized into two subsets. 1) Some are present in lymphoid tissues within germinal centres (GC ) structures. These cells are called follicular helper T cells (TFh cells) and are required […]
We all know that CD4 regulatory T cells (Tregs) are required to maintain immunologic homeostasis and prevent autoimmunity and inflammatory lesions. Tregs express the transcription factor Foxp3, and can be divided into CD4+CD25+Foxp3+ thymus-derived, natural regulatory T cells (nTregs) and extrathymically induced Tregs (iTregs) that are derived in the periphery from CD4+CD25−Foxp3− precursors. There is […]