Karine SERRE, PhD

IMMUNOLOGIST

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Peer-reviewed research and review articles:

37. P. Meireles, D. Brás, D. Fontinha, Â.F. Chora, K. Serre, A.M. Mendes, M. Prudêncio. (2020). “Elimination of Hepatic Rodent Plasmodium Parasites by Amino Acid Supplementation ”. Eur J Immunol. 257:120218 View this article online or download the PDF.
36. N.L. Alves, A. Carvalho, K. Serre, V.C. Martins, M. Saraiva. (2020). “The Portuguese Society for Immunology (SPI): history and mission”. Eur J Immunol. 257:120218 View this article online or download the PDF.
35. F. Castro, M.L. Pinto, C.L. Pereira, K. Serre, M.A. Barbosa, K. Vermael, F. Gärtner, R.M. Gonçalves, O. De Wever, M.J. Oliveira. (2020). “Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer”. Biomaterials 257:120218 View this article online or download the PDF.
34. V. Umansky, G. Adema, J. Baran, S. Brandau, J.A. van Ginderachter, X. Hu, J. Jablonska, S. Mojsilovic, H. Papadaki, Y. Pico de Coana, K. Santegoets, J. F Santibanez, K. Serre, Y. Si, I. Sieminska, M. Velegraki, Z. Fridlender. (2018). “Interactions among myeloid regulatory cells in cancer”. Cancer Immunology Immunotherapy 12th July, 1-16 View this article online or download the PDF.
33. S. Mensurado, M. Rei, T. Lança, N. Gonçalves-Sousa, H. Kubo, K. Serre* and B. Silva-Santos* (2018). “Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress”. PLOS Biology 16(5). View this article online or download the PDF. * Corresponding authors
32. F. Castro, A.P. Cardoso, R. Madeira Gonçalves, K. Serre and M.J. Oliveira. (2018). “Interferon-gamma at the crossroads of tumor immune surveillance or evasion.” Frontiers in Immunology Volume 9 | Article 847. View this article online or download the PDF.
31. N. Schmolka, P.H. Papotto, P. Vargas Romero, T. Amado, F.J. Enguita, A. Amorim, A.F. Rodrigues, K.E. Gordon, A.S. Coroadinha, M. Boldin, K. Serre, A.H. Buck, A.Q. Gomes and B. Silva-Santos. (2018). “MicroRNA-146a controls IFN-γ production and functional plasticity in γδ T cells by targeting Nod1.” Science Immunology 3(23). View this article online or download the PDF.
30. H. Kubo, S. Mensurado, N. Gonçalves-Sousa, K. Serre, B. Silva-Santos (2017). “Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells”. Cancer Immunol Res 5(9); 1-9. View this article online or download the PDF.
29. A. Ministro, P. Oliveira, R.J. Nunes, A. dos Santos Rocha, A. Correia, T. Carvalho, J. Rino, P. Faísca, J.D. Becker, J. Goyri-O’Neill, F. Pina, E. Poli, B. Silva-Santos, F. Pinto, M. Mareel, K. Serre, S. Constantino Rosa Santos (2017). “Low-dose ionizing radiation induces therapeutic neovascularization in a pre-clinical model of hindlimb ischemia”. Cardiovasc Res 1;113(7):783-794. View this article online or download the PDF.
28. J. Ribot, K. Serre, B. Silva-Santos (2017). “Developmental and Functional Assays to Study Murine and Human γδ T Cells”. Methods Mol Biol 1514:257-267. View this article online or download the PDF.
27. J. Barros-Martins, N. Schmolka, D. Fontinha, M. Pires de Miranda, J.P. Simas, I. Brok, C. Ferreira, M. Veldhoen, B. Silva-Santos*, K. Serre* (2016). “Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors”. J Immunology 196(9):3642-52. View this article online or download the PDF.
    * Corresponding authors
26. B. Silva-Santos*, K. Serre* and H. Norell (2015). “γδ T cells in cancer”. Nature Reviews Immunology 15: 683–691. View this article online or download the PDF.
    * Corresponding authors
25. A. Flores-Langarica, S. Bobat, J.L. Marshall, J.C. Yam-Puc, C.N. Cook, K. Serre, R.A. Kingsley, L. Flores-Romo, S. Uematsu, S. Akira, I.R. Henderson, K.M. Toellner, A.F. Cunningham. (2015). “Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production”. Eur J Immunol. 45(8):2299-311. View this article online or download the PDF.
24. K. Serre* and B. Silva-Santos*.
    “Molecular mechanisms of differentiation of murine pro-inflammatory γδ T cell subsets”
    Frontiers in Immunology (2013) 4:431. View this article online or download the PDF.
    * Corresponding authors
23. N. Schmolka#, K. Serre#, A.R Grosso, M. Rei, D.J. Pennington, A. Gomez and B. Silva-Santos.
    “Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets”
    Nature Immunology (2013) 14: 1093–1100. View this article online or download the PDF + supporting information.
    # Contributed equally to this work
22. K. Serre*, A.F. Cunningham, R.E. Coughlan, A.C. Lino, A. Rot, E. Hub, K. Moser, R. Manz, A. Ferraro, R. Bird, K.M. Toellner, J. Demengeot, I.C.M. MacLennan* and E. Mohr*.
    “CD8 T cells induce T-bet-dependent migration towards CXCR3 ligands by differentiated B cells produced during alum-protein vaccines.”
    Blood (2012) 120:4552-4559. View this article online or download the PDF.
    * Corresponding authors
21. K. Serre*, C. Benezech, G. Desanti, S. Bobat, K.M. Toellner, R. Bird, S. Chan, P. Kastner, A.F. Cunningham, I.C.M. MacLennan* and E. Mohr*.
    “Helios is associated with CD4 T cells differentiating into T helper 2 cells in vivo independently of Foxp3 expression.”
    PLoS One (2011) 6:e20731. Epub 2011 Jun 3. View this article online or download the PDF.
    * Corresponding author
20. K. Serre*, E. Mohr, C. Benezech, R. Bird, M. Khan, J.H. Caamaño, A.F. Cunningham and I.C.M. MacLennan.
    “Selective effects of NF-kB1 deficiency in CD4 T cells on Th2 and TFh induction by alum-precipitated protein vaccines.”
    Eur J Immunol (2011) 41:1573-1582. View this article online or download the PDF.
    * Corresponding authors
19. S. Bobat, A. Flores-Langarica, J. Hitchcock, J.L. Marshall, R.A. Kingsley, M. Goodall, C. Gil-Cruz, K. Serre, D.L. Leyton, S.E. Letran, F. Gaspal, R. Chester, G. Dougan, C. López-Macías, I.R. Henderson, J. Alexander, I.C.M. MacLennan, and A.F. Cunningham.
    “Soluble phase 1 flagellin, FliC, induces Th2 features yet promotes T-bet-regulated Th1 clearance of Salmonella Typhimurium infection.”
    Eur J Immunol (2011) 41:1606-1618.
    View this article online or download the PDF.
18. E. Mohr*, A.F. Cunningham, S. Bobat, K.M. Toellner, R. Bird, R.A. Manz, I.C.M. MacLennan and K. Serre*.
    “IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine.”
    Proc Natl Acad Sci U S A. (2010) 107:17292-17297. View this article online or download the PDF + supporting information.
    * Corresponding authors
17. K. Serre*, E. Mohr, F. Gaspal, P.J.L. Lane, R. Bird, A.F. Cunningham, and I.C.M. MacLennan.
    “IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo.”
    Mol Immunol (2010) 47:1914-1922. View this article online or download the PDF.
    * Corresponding author
16. C. Bénézech, A. White, E. Mader, K. Serre, S. Parnell, K. Pfeffer, C.F. Ware, G. Anderson, and J.H. Caamaño.
    “Ontogeny of Stromal Organizer Cells during Lymph Node Development.”
    J Immunol (2010) 184:4521-4530. View this article online or download the PDF.
15. K. Serre*, E. Mohr, K.M. Toellner, A.F. Cunningham, R. Bird, M. Khan, and I.C.M. MacLennan.
    “Early simultaneous production of intranodal CD4 Th2 effectors and recirculating rapidly-responding central-memory like CD4 T cells.”
    Eur J Immunol (2009) 39:1573–1586. View this article online or download the PDF.
    * Corresponding author
    A picture from this article made the cover of the Eur J Immunol issue 39
    
14. E. Mohr, K. Serre, R.A. Manz, A.F. Cunningham, M. Khan, D.L. Hardie, R. Bird, and I.C.M. MacLennan.
    “Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature.”
    J Immunol (2009) 182:2113-2123. View this article online or download the PDF.
    A picture from this article made the cover of the J Immunol issue 182
    
13. K. Serre*, E. Mohr*, K.M. Toellner, A.F. Cunningham, S. Granjeaud, R. Bird, and I.C. MacLennan.
    “Molecular differences between the divergent responses of ovalbumin-specific CD4 T cells to alum-precipitated ovalbumin compared to ovalbumin expressed by Salmonella.”
    Mol Immunol (2008) 45:3558-3566. View this article online or download the PDF.
    * Corresponding authors
12. S.A. Luther, K. Serre, A.F. Cunningham, M. Khan, H. Acha-Orbea, I.C. MacLennan, and K.M. Toellner.
    “Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells.”
    Eur J Immunol (2007) 37:1476-1484. View this article online or download the PDF.
11. A.F. Cunningham, F. Gaspal, K. Serre, E. Mohr, I.R. Henderson, A. Scott-Tucker, S.M. Kenny, M. Khan, K.M. Toellner, P.J. Lane, and I.C. Maclennan.
    “Salmonella Induces a Switched Antibody Response without Germinal Centers That Impedes the Extracellular Spread of Infection. »
    J Immunol (2007) 178:6200-6207. View this article online or download the PDF.
10. K. Serre, L. Giraudo, C. Siret, L. Leserman, and P. Machy.
    “CD4 T cell help is required for primary CD8 T cell responses to vesicular antigen delivered to dendritic cells in vivo.”
    Eur J Immunol (2006) 36:1386-1397. View this article online or download the PDF.
9. A.F. Cunningham, K. Serre, K.M. Toellner, M. Khan, J. Alexander, F. Brombacher, and I.C. MacLennan.
   “Pinpointing IL-4-independent and IL-4-influenced acquisition and maintenance of Th2 activity by CD4 T cells.”
   Eur J Immunol (2004) 34:686-694. View this article online or download the PDF.
8. A.F. Cunningham, K. Serre, E. Mohr, M. Khan, and K.M. Toellner.
   “Loss of CD154 impairs the Th2 extrafollicular plasma cell response but not early T cell proliferation and interleukin-4 induction.”
   Immunology (2004) 113:187-193. View this article online or download the PDF.
7. A.F. Cunningham, M. Khan, J. Ball, K.M. Toellner, K. Serre, E. Mohr, and I.C. Maclennan.
   “Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1. »
   Eur J Immunol (2004) 34:2986-2995. View this article online or download the PDF.
6. I.C. MacLennan, K.M. Toellner, A.F. Cunningham, K. Serre, D.M. Sze, E. Zuniga, M.C. Cook, and C.G. Vinuesa.
   “Extrafollicular antibody responses.”
   Immunol Rev (2003) 194:8-18. View this article online or download the PDF.
5. P. Machy,K. Serre, M. Baillet, and L. Leserman.
   “Induction of MHC class I presentation of exogenous antigen by dendritic cells is controlled by CD4+ T cells engaging class II molecules in cholesterol-rich domains.”
   J Immunol (2002) 168:1172-1180. View this article online or download the PDF.
4. L. Bungener, K. Serre, L. Bijl, L. Leserman, J. Wilschut, T. Daemen, and P. Machy.
   “Virosome-mediated delivery of protein antigens to dendritic cells.”
   Vaccine (2002) 20:2287-2295. View this article online or download the PDF.
3. P. Machy, K. Serre, and L. Leserman.
   “Class I-restricted presentation of exogenous antigen acquired by Fcgamma receptor-mediated endocytosis is regulated in dendritic cells.”
   Eur J Immunol (2000) 30:848-857. View this article online or download the PDF.
2. V.S. Zimmermann, P. Rovere, J. Trucy, K. Serre, P. Machy, F. Forquet, L. Leserman, and J. Davoust.
   “Engagement of B cell receptor regulates the invariant chain-dependent MHC class II presentation pathway.”
   J Immunol (1999) 162:2495-2502. View this article online or download the PDF.
1. K. Serre , P. Machy, J.C. Grivel, G. Jolly, N. Brun, J. Barbet, and L. Leserman.
   “Efficient presentation of multivalent antigens targeted to various cell surface molecules of dendritic cells and surface Ig of antigen-specific B cells.”
   J Immunol (1998) 161:6059-6067. View this article online or download the PDF.

Non-refereed review or comment:

2. E. Mohr, K. Serre, and I.C. MacLennan.
   Response to the Comments on « Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironment WherePlasmablasts Mature »
   J Immunol (2009) 182:5160. View this article online or download the PDF.
1. K. Serre, L. Giraudo, L. Leserman, and P. Machy.
   “Liposomes targeted to Fc receptors for antigen presentation by dendritic cells in vitro and in vivo.”
   Methods in enzymology (2003) 373:100-118. View this article online.

Publication in book chapter:

1. I.C. MacLennan, K. Serre, and E. Mohr.
   “Lymph nodes and the spleen; critical microenvironments in lymphomagenesis”.
   The Lymphoid Neoplasms (2009) 3rd Edition, Edited by Ian T. Magrath.

Publications in peer-reviewed conference proceedings and oral presentation:

• K. Serre, N. Schmolka, Ana Grosso, Margarida Rei, Daniel Pennington, A. Gomes and B. Silva-Santos (2013).
  “In vivo molecular signatures of stable versus plastic gamma delta T cell subsets that promote inflammation.” 1st IMM Post-doc Symposium 2013, October 17, Lisboa, PORTUGAL. Selected Oral Presentation over 100 post-docs.
• K. Serre, N. Schmolka, J. Ribot, A. Gomes and B. Silva-Santos (2013).
  “Regulation of IL-17 and IFN-γ expression in γδ T cells.” 16e Colloque Cytokines et Chimiokines du Croisic (CCCC16) 2013, May27-29, Croisic, FRANCE. invited Presentation.
• K. Serre, E. Mohr, K.M. Toellner, R. Bird, A.F. Cunningham and I.C. MacLennan (2009).
  “GATA-3, c-Maf, Helios mRNA expression related to Th2-cytokine control in T cells responding in vivo.”
  Germinal Centre Conference 16th GERMANY, 2009, July 5-9
• K. Serre, E. Mohr, K.M. Toellner, A.F. Cunningham, R. Bird, M. Khan and I.C. MacLennan (2007).
  “Early emergence of diversity in T cells making a primary Th2 response.”
  International Proceedings for the 13th International Congress of Immunology BRAZIL, 2007: 585-58
• K. Serre, L. Giraudo, S. Henri, P. Machy, and L. Leserman. (2003).
  “Dendritic cells capture and efficiently present antigen encapsulated in liposomes to T cells in vivo.”
  J Liposome Res for the 8th Liposome Research Days Conference USA, 2002: 13:21-23.
• K. Serre, P. Machy and L. Leserman. (2001)
  “In vitro and ex vivo characterization of dendritic cells as the major cell type responsible for liposome capture in lymph nodes and for presentation of liposome-encapsulated antigen to CD4+ and CD8+ T cells.”
  European Network of Immunology Institutes, ENII Conference FRANCE, 2001 May 17-21, Iles des Embiez.
• K. Serre, P. Machy, L. Leserman. (2000).
  “Présentation antigénique dans le contexte des molécules du CMH de classe II et de classe I par les cellules dendritiques in vitro et in vivo.”
  Club Francophone des Cellules Dendritiques (CFDC) FRANCE, 2000 November 27-28, Paris.
• K. Serre, P. Machy, J. Barbet and L. Leserman. (1997).
  “The antigen presenting functions of surface immunoglobulin on B cells and Fc receptors on dendritic cells are analogous”.
  Congrès Annuel de la Société Française d’Immunologie (SFI) FRANCE, 1997 November 26-28, Marseille.

This is the thesis for my PhD from 2002:

• Download the PDF (in French) : 3.5Mo

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